Volkar Mueller, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, discusses the incidence of brain metastases in patients with breast cancer, as presented at the European Society for Medical Oncology (ESMO) Breast Cancer Congress 2021. In this video, Dr Mueller highlights new therapeutic approaches in patients with HER2+ breast cancer with brain metastases such as tucatinib, neratinib and T-DM1, as well as the challenges associated with treating this patient population. This interview took place at the virtual ESMO Breast Cancer Congress 2021.