Benjamin Fairfax, BM BCh, MRCP, PhD, University of Oxford, Oxford, UK, discusses the findings of an investigation that aimed to characterize CD8 T-cell receptor signatures of response to immune checkpoint inhibitors. Deep sequencing of the T-cell receptor of CD8+ T-cells isolated from peripheral blood of patients receiving checkpoint inhibitor therapy revealed signatures that expand with immunotherapy and are associated with long-term clinical responses. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.
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