ESMO WCGIC 2023 | The role of CRC predicative biomarkers in guiding treatment decisions

Kristen Ciombor, MD, MSCI, Vanderbilt-Ingram Cancer Center, Nashville, TN, comments on the utility of current predicative biomarkers in developing treatment strategies for patients with colorectal cancer (CRC). High microsatellite instability (MSI-H) is currently the best indicator for robust responses to immunotherapy compared to PD-L1 and tumor mutational burden (TMB). However, patients with microsatellite stable (MSS) CRC with a very high TMB may additionally benefit from immunotherapy. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.

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