WCLC 2023 | First line pembrolizumab in PD-L1 TPS 90%+ NSCLC

Biagio Ricciuti, MD, Dana-Farber Cancer Institute, Boston, MA, discusses findings from a study which focuses on the efficacy of first-line pembrolizumab monotherapy in patients with advanced non-small cell lung cancer (NSCLC) based on their PD-L1 tumor proportion scores (TPS). Patients with PD-L1 TPS ≥90% were compared to those with TPS between 50-89%. Results from a cohort of 516 patients revealed that those with PD-L1 TPS ≥90% experienced significantly longer median progression-free survival (PFS) and overall survival (OS) compared to the 50-89% group. Furthermore, patients with very high PD-L1 expression were more likely to complete a full course of treatment. Genomic analysis showed differences in mutation frequencies, while immunophenotyping demonstrated increased immune cell activity in the ≥90% group. This research highlights the sustained benefits of pembrolizumab in high PD-L1 expression patients and underscores potential treatment implications. This interview took place at the 2023 World Conference on Lung Cancer (WCLC) in Singapore, Singapore.

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