Lorenza Rimassa, MD, Humanitas University and IRCCS Humanitas Research Hospital Rozzano, Milan, Italy, discusses the ongoing Phase II NMS-153 trial (NCT05630937), which is studying patients with advanced hepatocellular carcinoma (HCC) previously treated with other systemic therapies. The drug NMS-01940153E has a novel mechanism of action and functions by blocking cellular replication. The aim of the NMS-153 trial is to confirm the findings of Phase I studies and test for efficacy, before moving onto combination therapy in different scenarios. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.
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