SITC 2023 | AMBER: anti-TIM3 antibody reverses T-cell exhaustion in NSCLC

Diwakar Davar, MD, University of Pittsburgh School of Medicine, Pittsburgh, PA, discusses findings from the AMBER trial (NCT02817633) of cobolimab, an anti-TIM-3 monoclonal antibody, alone or with PD-1 inhibitors in patients with non-small cell lung cancer (NSCLC). Cobolimab plus dostarlimab combination therapy in patients with NSCLC previously treated with anti-PD(L)-1 therapy returned some evidence of efficacy and progression-free survival with responders having higher expression of TIM3. The treatment was safe and produced pharmacodynamic evidence that the drug worked as intended, with increased T-cell engagement. The Phase II COSTAR Lung (NCT04655976) trial is administering this therapy in addition to docetaxel to assess its impact. This interview took place at the Society for Immunotherapy of Cancer’s (SITC) 38th Annual Meeting in San Diego, CA.

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