Robert Huddart, PhD, FRCR, MRCP, MBBS, The Royal Marsden Hospital and The Institute of Cancer Research, London, UK, discusses the cost-effectiveness of alternative imaging and surveillance schedules for testicular seminoma as evaluated using the data from the Phase III TRISST (NCT00589537) trial. 669 men were randomized to 4 surveillance groups undergoing 7 CTs over 5 years, 3 CTs over 3 years, 7 MRIs, or 3 MRIs of the retroperitoneum. Resource use and health outcomes data on each patient were collected at baseline and over a period of 6 years after randomization. Overall, the study showed differences exist in total costs and quality of life between different strategies. A 7 scan MRI schedule yielded more health benefits than other strategies, but at higher costs. Considering possible capacity constraints with MRI, the reduced radiation exposure relative to CT, and non-inferiority for clinical outcomes in the primary analysis, a 3 scan MRI schedule may be the superior option to replace current CT-based longer surveillance practice. This interview took place at the ASCO GU Cancers Symposium 2023 in San Francisco, CA.
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