Breelyn Wilky, MD, University of Colorado Anschutz Medical Campus, Aurora, CO, provides an overview of the Phase II MEDISARC trial (NCT03317457), which assessed durvalumab and tremelimumab in patients with advanced or metastatic soft tissue sarcoma. The investigational therapy was found to have similar clinical activity in patients compared to doxorubicin. Dr Wilky additionally discusses the Phase II TOMAS2 trial (NCT03838744) of trabectedin with or without olaparib, a PARP inhibitor, in patients with soft tissue sarcomas (STS). Addition of olaparib was found to improve outcomes in patients with DNA repair defects. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.
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