So the PRINCE study, to those who aren’t familiar, is a Phase I trial, fully accrued and completed, and in follow up now of treatment for metastatic castration resistant, prostate cancer. It’s combining two therapies. One is Lutetium PSMA radioligand treatment with the checkpoint inhibitor, pembrolizumab. This population of patients are men with castration-resistant prostate cancer who have progressed after an androgen receptor signaling inhibitor, and they may have progressed after chemotherapy like docetaxel as well...
So the PRINCE study, to those who aren’t familiar, is a Phase I trial, fully accrued and completed, and in follow up now of treatment for metastatic castration resistant, prostate cancer. It’s combining two therapies. One is Lutetium PSMA radioligand treatment with the checkpoint inhibitor, pembrolizumab. This population of patients are men with castration-resistant prostate cancer who have progressed after an androgen receptor signaling inhibitor, and they may have progressed after chemotherapy like docetaxel as well. The PRINCE study, which is being presented at ASCO 2022 as well today does show significant activity for that combination in castration-resistant disease. The focus of our substudy was to look at correlatives of that trial, in particular profiling of circulating tumor cells and PET metrics as potential prognostic and predictive biomarkers for combined Lutetium plus pembrolizumab therapy.