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ESMO 2022 | KEYNOTE-061: association between gene expression signatures & outcomes

Kohei Shitara, MD, National Cancer Center Hospital East, Kashiwa, Japan discusses the association between gene expression signatures and outcomes of pembrolizumab and paclitaxel, in patients with advanced gastric or gastro-esophageal cancer with high PD-1 level expression. The gene expression profile (GEP) showed some association with clinical outcomes of pembrolizumab but not paclitaxel. Dr Shitara also talks about the negative associations for each drug and suggests that myeloid-driven suppression could be influential in the resistance to PD-1 inhibition. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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