ESMO Asia 2023 | PERLA trial outcomes in global and Asian subgroup populations

Beung Chul Ahn, MD, National Cancer Center, Seoul, South Korea, summarizes the outcomes of the Phase II PERLA trial (NCT04581824), the first global double-randomized study comparing the efficacy of PD-1 inhibitors dostarlimab and pembrolizumab in patients with non-small cell lung cancer (NSCLC). Treatment was administered alongside chemotherapy (CT) and progression-free survival (PFS) measured as the primary endpoint. Subgroup analyses in Asian populations support the hypotheses of this trial, although small sample sizes support the requirement for further studies into dostarlimab and CT treatment. With immunotherapy and CT as the current first-line treatment, further studies combining and comparing this with dostarlimab should be considered. This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.

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