Ari Rosenberg, MD, Yale School of Medicine, New Haven, CT, discusses findings from the Phase II DEPEND trial (NCT03944915), which assessed neoadjuvant nivolumab, paclitaxel, and carboplatin followed by response-stratified chemoradiation in patients with advanced HPV-negative head and neck squamous cell carcinoma (HNSCC). Nivolumab-based neoadjuvant chemoimmunotherapy resulted in deep responses, and response-adapted CRT led to promising survival. PD-1 status was additionally associated with deep responses. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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