Shengqing Gu, PhD, Dana-Farber Cancer Institute, Boston, MA, discusses the potential role of the CRISPR technology in oncology. In the context of immunotherapy, CRISPR approaches could be used to identify the genes modulating the immune response in cancer. Dr Gu emphasizes on the importance of combining CRISPR with computational biology approaches to make sense of the data obtained with this technology. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.