The landscape of ovarian cancer treatment is rapidly changing, with PARP inhibitors moving into the first-line setting and new research addressing homologous recombination deficiency-positive patients. Concurrently, translational medicine seeks to optimize treatment strategies by comparing combination therapies and immunotherapies, says Domenica Lorusso, MD, PhD, of the IRCCS National Cancer Institute, Milan, Italy. This interview took place at the European Society for Medical Oncology (ESMO) 2018 Congress, in Munich, Germany.