WCLC 2023 | EVOKE-02: sacituzumab govitecan and pembrolizumab in first-line NSCLC

Byoung Chul Cho, MD, PhD, Yonsei University College of Medicine, Seoul, South Korea, provides an overview of findings from the Phase II EVOKE-02 trial (NCT05186974) of sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate (ADC), and pembrolizumab in patients with metastatic non-small cell lung cancer (NSCLC). Patients were divided into two cohorts, where cohort A consisted of patients with a PD-L1 tumor proportion score (TPS) of more than 50%, and cohort B consisted of patients with a PD-L1 TPS of less than 50%. The investigational regimen showed promising safety and efficacy in both cohorts, and a higher overall response rate was observed in cohort A. This interview took place at the 2023 World Conference on Lung Cancer (WCLC) in Singapore, Singapore.

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