Lorenza Rimassa, MD, Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy, discusses recent positive trials of immunotherapy plus chemotherapy for patients with cholangiocarcinoma, as well as developments in targeted therapies and the advent of molecular profiling. This interview took place at the European Society for Medical Oncology World Congress on Gastrointestinal Cancer (ESMO WCGIC) 2022 in Barcelona, Spain.