Michele Ghidini, MD, PhD, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy, outlines areas of unmet needs for patients with gastrointestinal (GI) cancers, including the availability of effective second-line therapies, as well as the potential of immunotherapy to rectify this. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).