GU Cancers 2024 | Emerging biomarkers of ADC response and toxicity in urothelial carcinoma

Enrique Grande, MD, PhD, MD Anderson Cancer Centre Madrid, Madrid, Spain, provides an update on biomarkers for antibody-drug conjugates (ADC) used in urothelial carcinoma, which are necessary to identify patients who will benefit from treatment and reduce toxicity. Whilst the Phase III EV-302 trial (NCT04223856) failed to elucidate novel biomarkers, nectin-4 and circulating tumor DNA (ctDNA) have been subsequently identified as potential biomarkers. Dr Grande additionally highlights radioligands as a promising strategy to find biomarkers. This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.

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