The hepatocellular carcinoma (HCC) treatment landscape has expanded in all settings, with multi-kinase and immune checkpoint inhibitors taking center stage. At the European Society for Medical Oncology (ESMO) 2018 Congress, in Munich, Germany, Michael Pishvaian, MD, PhD, of Georgetown University, Washington, WA, discusses the efficacy and limitations of emerging agents such as bevacizumab, regorafenib and lenvatinib, as well as their role in disease biology and combination regimens.