Michael Pishvaian, MD, PhD, of Georgetown University, Washington, WA, describes the process and outcomes of the Phase 1b trial (NCT02715531) investigating the combination of bevacizumab and atezolizumab for advanced hepatocellular carcinoma (HCC) patients, at the European Society for Medical Oncology (ESMO) 2018 Congress, in Munich, Germany. With a tolerable safety profile, encouraging response rates and durable responses, this may be a promising first-line treatment option for patientss with advanced HCC. The Phase III IMbrave150 trial (NCT03434379) is currently recruiting.