Joseph Sparano, MD, Icahn School of Medicine at Mount Sinai, New York, NY, shares an update on the Phase III TAILORx (NCT00310180) trial that included 10,273 woman with ER-positive, lymph node-negative breast cancer, and are candidates to receive adjuvant systemic chemotherapy in addition to endocrine therapy in order to reduce risk of recurrence. All patients had the 21-gene Oncotype DX Recurrence Score guiding their treatment. The study was designed to address where there was therapeutic equipoise. Patients who had a recurrence score of 11-25 were randomized to receive either chemotherapy plus endocrine therapy or endocrine therapy alone. The primary results reported 4 years ago revealed that endocrine monotherapy was non-inferior to chemotherapy plus endocrine therapy. The updated analysis with 3.5 years further follow-up showed that the primary results remain unchanged, and patients continued to exhibit a risk of recurrence beyond 5 years. Additionally, racial disparities were revealed between Black and White woman. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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