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AACR 2024 | Novel immunotherapeutic approaches to treat patients with melanoma

Christoffer Gebhardt, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, discusses the emerging efficacy and clinical translation of tumor-infiltrating lymphocyte (TIL) therapeutic lifileucel. Outlining the current clinical approval status of lifileucel, Prof. Gebhardt notes that a planned Phase III trial combining anti PD-1 monotherapy pembrolizumab and lifileucel may hold promise as a first-line treatment for patients with metastatic melanoma. Although the selection criteria and markers are not yet characterized, TIL therapy may be particularly beneficial to a selected group of patients with melanoma. Prof. Gebhardt additionally highlights TCR-engineered T cell therapies and bi-specific immunotherapies are also being developed. This interview took place at the 2024 American Association for Cancer Research (AACR) in San Diego, CA.

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