Jason Luke, MD, FACP, UPMC Hillman Cancer Center, Pittsburgh, PA, describes the mechanism of action of the PDL1-IL15 bispecific molecule, KD033. Early dose-escalation clinical trial data of PDL1-IL15 have demonstrated responses in the form of fevers and chills and even disease regression in some patients. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.