ESMO 2023 | How much progress have we made in targeting KRAS in GI malignancies?

Benedikt Westphalen, MD, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany, discusses advances in targeting KRAS. The advent of KRAS inhibitors, such as G12C and pan-KRAS inhibitors, have been massively beneficial across the field of oncology, especially in pancreatic cancer. Findings from the Phase III CodeBreak300 trial (NCT05198934) of sotorasib and panitumumab in KRAS G12C-mutant colorectal cancer have demonstrated the potency of KRAS inhibition. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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