Neal Sean McCall, MD, Winship Cancer Institute, Emory University, Atlanta, GA, shares his highlights from the IASLC 2022 World Conference on Lung Cancer congress, including on oligometastatic disease sessions, the use of ablative local therapies and designing trials in the future in order to isolate different groups of patients to understand disease biology between subgroups of patients. This interview took place at the IASLC 2022 World Conference on Lung Cancer congress in Vienna, Austria.