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ASCO 2026 | ctDNA improves detection and prognostication of sarcoma recurrence

Maggie Zhou, MD, Stanford University School of Medicine, Stanford, CA, comments on the challenges of identifying true disease recurrence in patients with sarcoma using imaging alone, and notes that circulating tumor DNA (ctDNA) detection can help predict and prognosticate patient outcomes, particularly in cases such as retroperitoneal leiomyosarcoma. ctDNA can be useful in distinguishing between post-surgical changes and residual disease, enabling more informed conversations with patients. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So sarcoma patients are unique in that sometimes there can be some difficulty in ascertaining on imaging alone, whether there is true disease recurrence. So for instance, for patients with retroperitoneal leiomyosarcoma to undergo curative intent surgery, sometimes the first imaging might find something that is concerning, but it’s unclear whether that’s purely post-surgical changes or whether that’s concerning for residual disease...

So sarcoma patients are unique in that sometimes there can be some difficulty in ascertaining on imaging alone, whether there is true disease recurrence. So for instance, for patients with retroperitoneal leiomyosarcoma to undergo curative intent surgery, sometimes the first imaging might find something that is concerning, but it’s unclear whether that’s purely post-surgical changes or whether that’s concerning for residual disease. And I have found that for positive ctDNA detection, that can really help predict and help prognosticate patients’ care and help me set up conversations for patients.

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