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ASCO 2026 | Sarcoma highlights at ASCO 2026: SARC-041, PEAK, and RINGSIDE

Maggie Zhou, MD, Stanford University School of Medicine, Stanford, CA, provides an overview of top sarcoma trials presented including the SARC-041 study (NCT04967521), which supports abemaciclib as a new treatment option for dedifferentiated liposarcoma. Additional trials include the PEAK trial (NCT05208047) of bezuclastinib and sunitinib versus sunitinib alone in patients with advanced gastrointestinal stromal tumors (GIST) and the RINGSIDE trial (NCT04871282) of varegacestat in desmoid tumors. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

This has been a really exciting year for ASCO. It’s not common that sarcoma makes it into the literature, so we were really excited to have the results of SARC-041 be presented by Dr. Mark Dickson from Memorial Sloan Kettering. This really establishes a new potential standard of care for dedifferentiated liposarcoma with the demonstration of abemaciclib and gemcitabine over placebo for these patients...

This has been a really exciting year for ASCO. It’s not common that sarcoma makes it into the literature, so we were really excited to have the results of SARC-041 be presented by Dr. Mark Dickson from Memorial Sloan Kettering. This really establishes a new potential standard of care for dedifferentiated liposarcoma with the demonstration of abemaciclib and gemcitabine over placebo for these patients. We know for these patients that doxorubicin has marginal benefit for many patients, and I think abemaciclib really provides a promising new option for these patients. Otherwise, in the oral abstract sessions, very notable trials, I think, that were highlighted were the PEAK study for bezuclastinib and sunitinib compared to sunitinib alone, which has a very promising potential to transform care as well. And of course, the immunotherapy study with varegacestat also provides new armamentarium for our patients.

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