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ESMO 2022 | DURIGAST: 2L FOLFIRI plus durvalumab plus tremelimumab in GC or GE junction adenocarcinoma

David Tougeron, MD, PhD, Poitiers University Hospital, Poitiers, France, provides an overview of the Phase II PRODIGE 59-DURIGAST (NCT03959293) trial investigating FOLFIRI with durvalumab with or without tremelimumab in the second-line of patients with advanced gastric or gastro-oesophageal junction adenocarcinoma. The primary endpoint was progression-free survival (PFS) at 4 months and secondary outcomes was overall-survival (OS). The primary endpoint was not met in either month, however, PFS was 5 months and OS was almost 1 year. These results are better than chemotherapy alone, suggesting FOLFIRI with two immune checkpoint inhibitors should be evaluated in the second-line setting. Biomarker analysis is ongoing to evaluate the 20-30% of patients with good response to the combination of FOLFIRI plus durvalumab with tremelimumab. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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