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ESMO 2024 | PEACE-1: prognostic biomarkers in de novo metastatic prostate cancer

Cedric Pobel, MD, Gustave Roussy, Villejuif, France, discusses the identification of prognostic biomarkers for radiographic progression-free survival (rPFS) and overall survival (OS) in the PEACE-1 trial (NCT01957436). In patients with metastatic castration-sensitive prostate cancer (mCSPC), neuroendocrine marker positivity was associated with worse outcomes, while ERG positivity correlated with longer radiographic progression-free survival (rPFS). No biomarkers predicted response to abiraterone acetate and prednisone. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.

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