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ESMO 2022 | IMvigor130: a post-hoc analysis of atezolizumab monotherapy in urothelial carcinoma

Enrique Grande, MD, PhD, MSc, MD Anderson Cancer Center Madrid, Madrid, Spain, discusses a post-hoc analysis of the Phase III IMvigor130 (NCT02807636) trial which explored atezolizumab as monotherapy and in combination with platinum-based chemotherapy in participants with untreated locally advanced or metastatic urothelial carcinoma, demonstrating a trend in favorable overall-survival (OS) with atezolizumab monotherapy. In this post-hoc analysis, the immunological basis underlying the trend in favorable OS with atezolizumab monotherapy was investigated, through studying associations between two PD-L1 immunohistochemistry tests (VENTANA SP142 and Dako 22C3) and OS in patients with archival tumors in IMvigor130. Different OS trends were observed with different PD-L1 assays. PD-L1–expressing DCs may underlie the longer OS with atezolizumab in SP142 IC2/3 versus IC0/1 tumours in patients with mUC. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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