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Jason J. Luke, MD, FACP, University of Pittsburgh, Pittsburgh, PA, summarises the KEYNOTE-716 trial (NCT03553836) comparing pembrolizumab to placebo for high-risk melanoma. Treatment with pembrolizumab resulted in a 35% reduction in risk of recurrence compared to placebo. This interview took place at the European Society for Medical Oncology (ESMO) 2021 congress.
Disclosures
Dr Luke reports DSMB: Abbvie, Immutep. Scientific Advisory Board: (no stock) 7 Hills, Fstar, Inzen, RefleXion, Xilio (stock) Actym, Alphamab Oncology, Arch Oncology, Kanaph, Mavu, Onc.AI, Pyxis, Tempest.
Dr Luke reports research support: (all to institution for clinical trials unless noted) AbbVie, Agios (IIT), Astellas, Astrazeneca, Bristol-Myers Squibb (IIT & industry), Corvus, Day One, EMD Serono, Fstar, Genmab, Ikena, Immatics, Incyte, Kadmon, KAHR, Macrogenics, Merck, Moderna, Nektar, Next Cure, Numab, Pfizer (IIT & industry) Replimmune, Rubius, Scholar Rock, Synlogic, Takeda, Trishula, Tizona, Xencor/
Dr Luke reports patents: (both provisional) Serial #15/612,657 (Cancer Immunotherapy), PCT/US18/36052 (Microbiome Biomarkers for Anti-PD-1/PD-L1 Responsiveness: Diagnostic, Prognostic and Therapeutic Uses Thereof)
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