SITC 2022 | Targeting cold tumors with anti-PVRIG immunotherapy

Poliovirus receptor-related immunoglobulin domain-containing (PVRIG) is a novel immune checkpoint receptor predominantly expressed in stem-like memory T cells. Eran Ophir, PhD, Compugen Ltd., Tel Aviv, Israel, comments on targeting PVRIG with immunotherapies in immunologically cold tumors. Stem-like memory T cells are mainly localized in the tumor microenvironment and preliminary data assessing COM701 in solid tumors including microsatellite stable colorectal cancer have shown PVRIG to be a promising target. This interview took place at the 37th Annual Meeting of the Society for Immunotherapy in Cancer (SITC 2022) in Boston, MA.

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