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ASCO 2023 | Neoadjuvant biomarker analysis of NeoRHEA: palbociclib in ER+/HER2- BC

Elisa Agostinetto, MD, Institut Jules Bordet, Brussels, Belgium, discusses biomarker findings from the Phase II NeoRHEA trial (NCT03065621) of palbociclib with endocrine therapy in patients with ER+/HER2- breast cancer (BC). 100 patients were enrolled, and identification of biomarkers of no response was the primary endpoint. Cell cycle arrest was observed in a majority of patients, highlighting the efficacy of CDK4/6 inhibitors. High mRNA expression of the CDK6 gene was associated with poor response. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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