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ASCO GI 2023 | NRG/RTOG 1112: sorafenib vs SBRT followed by sorafenib in HCC

Laura A. Dawson, MD, FASTRO, Princess Margaret Cancer Centre, Toronto, Canada, discusses the results of the NRG/RTOG 1112 randomized Phase III study (NCT01730937) of sorafenib vs. stereotactic body radiation therapy (SBRT) followed by sorafenib in hepatocellular carcinoma (HCC). Compared to sorafenib alone, SBRT improved overall survival & progression-free survival in patients with HCC, with no observed increase in adverse events, and a strong suggestion for quality of life benefit at 6 months. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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