Anusha Chidharla, MBBS, University of Kansas Medical Center, Kansas City, MO, dsicusses the use of belzutifan in VHL-associated tumors. Belzutifan shows higher efficacy and better safety compared to VEGF TKIs like sunitinib and pazopanib in VHL-associated tumors. Real-world evidence shows belzutifan is well-tolerated, with minimal side effects such as anemia and fatigue. belzutifan can be a viable systemic alternative, potentially reducing the need for surgery in these patients and improving their quality of life. During the median eight-month follow-up of the real-world study on belzutifan in VHL-associated tumors, none of the patients required surgery, indicating its potential as an effective and non-invasive treatment option. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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