Jonathan Rosenberg, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, outlines data on upper tract urothelial carcinoma (UTUC) neoadjuvant treatment. Data presented at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers (GU) Symposium 2022, strongly supports the use of perioperative chemotherapy for UTUC. However, many patients are ineligible for postoperative platinum-based chemotherapy following resection and can better tolerate the process of chemotherapy in the neoadjuvant setting. The survival outcome of advanced UTUC is poor and neoadjuvant chemotherapy could provide a new treatment approach that could benefit this patient population. This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.