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ESMO Asia 2022 | EXTREME regimen vs. cetuximab + cisplatin + paclitaxel for recurrent/metastatic head and neck cancer

Avinash Khadela, PhD, L.M. College Of Pharmacy, Ahmedabad, India, explains a study comparing the EXTREME regimen to a paclitaxel-based regimen for patients with recurrent or metastatic head and neck squamous cell carcinoma. Patients were divided into two cohorts. Cohort 1 received the EXTREME regimen of cetuximab, cisplatin, and 5-fluorouracil (5-FU) while Cohort 2 received cetuximab, cisplatin, and paclitaxel. Dr Khadela discusses the rationale behind replacing 5-FU with paclitaxel and talks on previous studies in which 5-FU has been replaced by docetaxel. In this study, the paclitaxel-based regimen was found to lead to no improvement in overall survival but did result in a significant improvement in progression-free survival. This interview took place at the European Society for Medical Oncology (ESMO) Asia congress 2022 in Singapore.

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