ESMO 2023 | Predictive biomarkers for RAS-wt mCRC treated with cetuximab and m-FOLFOXIRI

Yu Sunakawa, MD, PhD, St. Marianna University School of Medicine, Kawasaki, Japan, presents findings from a biomarker analysis from the Phase II DEEPER trial (NCT02515734). The trial assessed cetuximab versus bevacizumab with modified (m)-FOLFOXIRI in patients with previously untreated metastatic colorectal (mCRC) with RAS wild-type (wt) tumors. In the cetuximab arm, a higher depth of response was reported in patients with RAS/BRAF wild-type and left-sided tumors. Male patients or people with extra-hepatic metastases may also benefit more from cetuximab with m- FOLFOXIRI. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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