Pat W. Whitworth, MD, Vanderbilt University Medical Center, Nashville, TN, talks on key takeaways from the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting, including the Phase III DESTINY-Breast04 (NCT03734029) trial, which demonstrated a survival benefit with trastuzumab deruxtecan versus chemotherapy in patients with HER2-low breast cancer. Dr Whitworth also mentions the Phase II trial (NCT04165772) exploring the induction of PD-1 blockade in subjects with locally advanced mismatch repair deficient locally advanced rectal cancer, which demonstrated a highly impressive 100% complete response rate. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.