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ESMO 2023 | Targeted therapies for cholangiocarcinoma in the second line setting

Lorenza Rimassa, MD, Humanitas University, Milan, Italy, comments on the development of targeted therapies for patients with cholangiocarcinoma (CCA) pre-treated with cisplatin and gemcitabine. Pemigatinib and futibatinib have both been approved for FGFR2-mutant bile duct cancer and ivosidenib has been approved for CCA with an IDH1 mutation. Phase II trials have additionally assessed trastuzumab deruxtecan and pertuzumab with trastuzumab in HER-2-mutant CCA. Trametinib has also been investigated to treat BRAF-mutant CCA. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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