Matteo Lambertini, MD, PhD, IRCCS AOU San Martino (Ospedale Policlinico San Martino), Genova, Italy, provides a round-up of key presentations from the SABCS 2020 virtual meeting, including results from the monarchE trial (NCT03155997), as well as PENELOPE-B (NCT01864746), as well as studies evaluating genomic data and how this can be translated into clinical practice. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).