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ESMO 2023 | TALAPRO-2: exposure-safety of talazoparib + enzalutamide in mCRPC

Arun Azad, PhD, Peter MacCallum Cancer Centre, Melbourne, Australia, discusses the exposure safety and efficacy results from the Phase III TALAPRO-2 (NCT03395197) trial, evaluating the use of talazoparib and enzalutamide as a combination therapy to treat patients with metastatic, castration-resistant prostate cancer. the combination of talazoparib (a PARP inhibitor) with enzalutamide improved progression-free survival in patients with metastatic castration-resistant prostate cancer. However, a significant number of patients experienced dose interruptions or reductions of talazoparib due to adverse events (AEs), particularly Grade 3 or higher Anemia, Thrombocytopenia, and Neutropenia. This study analyzed data from 412 patients to investigate the relationship between talazoparib exposure and these AEs. They used time-varying average talazoparib concentrations (Cavg,t) and found that higher Cavg,t was associated with a higher risk of these AEs. Other factors like baseline hemoglobin, body weight, and lactate dehydrogenase levels were also linked to increased risk. The findings support a dose modification approach for managing AEs in these patients. Dr Azad stresses the need to find a balance between optimal drug efficacy and treatment-related toxicities such as anemia. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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