Wolfgang Janni, MD, PhD, Ulm University, Ulm, Germany, highlights the exciting new updates presented at the San Antonio Breast Cancer Symposium (SABCS) 2020, including the use of endocrine combination therapy in breast cancer as evaluated in the monarchE (NCT02107703) and PENELOPE-B studies (NCT01864746), as well as the use of adjuvant chemotherapy in node-positive patients as presented in the RxPONDER (NCT01272037) and ADAPT studies presented at this years meeting. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).