Paul Bunn, MD, University of Colorado Cancer Center, Aurora, CO, gives an overview of he is looking forward to at the 2022 Targeted Therapies of Lung Cancer Meeting (TTLC22), including updates in tyrosine kinase inhibitors (TKIs), mechanisms of resistance to TKIs, and novel therapies to counter TKI-resistant lung cancer. Prof. Bunn additionally addresses strategies to overcome central nervous system (CNS) metastases, alternative biomarkers to PD-L1, as well as antibody drug conjugates. This interview took place at TTLC 2022.