Ken Herrmann, MD, MBA, Universitätsklinikum Essen, Essen, Germany discusses three different tracers (Gallium-PSMA-11, PyL, and fluorinated-PSMA-1007) currently used in PET-based imaging for prostate cancer. Prof. Herrmann describes the differences in the labelling and excretion of these different tracers, and the implications of this in terms of clinical use. This interview took place at the APCCC 2022 conference, held in Lugano, Switzerland.