Kristen Keon Ciombor, MD, Vanderbilt Health, Nashville, TN, comments on the potential role of neoadjuvant immunotherapy in patients with microsatellite instability (MSI)-high colorectal cancer. Dostarlimab has proven to be efficacious in MSI-high colorectal cancer, and further studies have suggested immunotherapy to be beneficial in the neoadjuvant setting. However, additional research is required to elucidate the optimal duration of treatment, and who will benefit most. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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