Jeroen Dekervel, MD, PhD, KU Leuven, Leuven, Belgium, comments on factors affecting individualized first-line systemic treatment for patients with advanced hepatocellular carcinoma. A variety of treatment options exist, including immunotherapies with PD-1 and CTLA-4 inhibition and VEGF inhibitors. Dr Dekervel highlights importance of elucidating tumor and liver characteristics and the need for biomarkers, which can guide clinical decision-making. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.
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