Pavlos Msaouel, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX, reflects on key takeaways in renal cell carcinoma at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting, including the importance of treatment sequencing as well as refining clinical endpoints and methodologies. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.