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SABCS 2022 | OP-1250: a small molecule oral complete estrogen receptor antagonist (CERAN)

Sean Bohen, MD, PhD, Olema Oncology, San Francisco, CA, provides an overview of OP-1250, a complete estrogen receptor antagonist (CERAN). When it binds to the estrogen receptor (ER), it completely turns off the cell growth and proliferation signal mediated by the ER in ER-positive breast cancer cells. It additionally acts as a potent selective estrogen receptor degrader (SERD). OP-1250 is currently being developed as both a single agent and in combination with CDK4/6 inhibitors and a PI3K-alpha inhibitor. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.

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