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ASCO 2026 | Using Decipher to personalize therapy in early prostate cancer

Daniel Keizman, MD, Ichilov–Sourasky Medical Center, Tel Aviv, Israel, discusses the utility of the Decipher test in determining the intensity of therapy in early prostate cancer. The test should be considered for use in these patients to inform treatment decisions, and transcriptomic profile differences is subsequently an area for further hypothesis generation and validation in larger cohorts. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

Yeah, so the Decipher is already, I would say, a standard approach to try and give us information whether we should intensify therapy or de-intensify therapy. And here we see that also in non-American patients, the test performs well, and we should consider doing the test also in these patients. Regarding the transcriptomic profile differences, this is just a hypothesis-generating and down the road it should be validated also in larger cohorts before we can conclude any definitive conclusions...

Yeah, so the Decipher is already, I would say, a standard approach to try and give us information whether we should intensify therapy or de-intensify therapy. And here we see that also in non-American patients, the test performs well, and we should consider doing the test also in these patients. Regarding the transcriptomic profile differences, this is just a hypothesis-generating and down the road it should be validated also in larger cohorts before we can conclude any definitive conclusions.

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